Author

D. S. W. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

C. P. brangwynne· 4 shared N. S. Wingreen· 3 shared J. A. Riback· 2 shared L. Beckers· 2 shared C.-H. Choi· 1 shared D. W. Sanders· 1 shared J. M. Eeftens· 1 shared L. A. Becker· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiophysics

C. P. brangwynne

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4 papers

Recent·Most cited

A rich get richer effect governs intracellular condensate size distributions

D. S. W. Lee, C.-H. Choi, D. W. Sanders, L. Beckers, J. A. Riback, C. P. brangwynne, N. S. Wingreen

The paper investigates condensate size distributions in cells and finds that exponential and power-law distributions arise from different physical mechanisms, with the latter linked to a 'rich get richer' effect.

bioRxiv · Mar 8, 2022 · PreprintBiophysics

Viscoelastic RNA entanglement and advective flow underlie nucleolar form and function

J. A. Riback, J. M. Eeftens, D. S. W. Lee, S. A. Quinodoz, L. Beckers, L. A. Becker, C. P. Brangwynne

The paper maps nucleolar rRNA dynamics using imaging and modeling, finding that rRNA moves radially due to viscoelastic properties and polymerization, leading to a new model for rRNA release.

bioRxiv · Dec 31, 2021Biophysics

Mechanical frustration of phase separation in the cell nucleus by chromatin

Y. Zhang, D. S. W. Lee, Y. Meir, C. P. Brangwynne, N. S. Wingreen

The paper investigates how chromatin mechanics suppress phase separation in the nucleus and control droplet properties through theory and simulation.

bioRxiv · Dec 24, 2020Biophysics

Chromatin Mechanics Dictates Subdiffusion and Coarsening Dynamics of Embedded Condensates

D. S. W. Lee, N. S. Wingreen, C. P. Brangwynne

This study shows that chromatin mechanics slow down condensate coarsening by inhibiting droplet growth and causing subdiffusion, with implications for biophysical regulation of condensates.

bioRxiv · Jun 3, 2020Biophysics