Author

D. W. Sanders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. P. brangwynne· 3 shared J. A. Riback· 2 shared A. Donlic· 1 shared A. H. Tavares· 1 shared A. Ploss· 1 shared A. S. Holehouse· 1 shared B. D. Levy· 1 shared C. C. Jumper· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

C. P. brangwynne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A rich get richer effect governs intracellular condensate size distributions

D. S. W. Lee, C.-H. Choi, D. W. Sanders, L. Beckers, J. A. Riback, C. P. brangwynne, N. S. Wingreen

The paper investigates condensate size distributions in cells and finds that exponential and power-law distributions arise from different physical mechanisms, with the latter linked to a 'rich get richer' effect.

bioRxiv · Mar 8, 2022 · PreprintBiophysics

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

I. Saha, P. Yuste-Checa, M. da Silva Padilha, Q. Guo, R. Körner, H. Holthusen, V. A. Trinkaus, I. Dudanova, R. Fernandez-Busnadiego, W. Baumeister, D. W. Sanders, S. Gautam, M. I. Diamond, F.-U. Hartl, M. S. Hipp

This study shows that the AAA+ chaperone VCP disaggregates Tau fibrils and generates seeding-active Tau as a byproduct, suggesting a role in aggregate removal and spreading in tauopathies.

bioRxiv · Feb 18, 2022Cell Biology

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

D. W. Sanders, C. C. Jumper, P. J. Ackerman, D. Bracha, A. Donlic, H. Kim, D. Kenney, I. Castello-Serrano, S. Suzuki, T. Tamura, A. H. Tavares, M. Saeed, A. S. Holehouse, A. Ploss, I. Levental, , C. P. Brangwynne

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

bioRxiv · Dec 14, 2020Cell Biology

Composition dependent phase separation underlies directional flux through the nucleolus

J. A. Riback, L. Zhu, M. C. Ferrolino, M. Tolbert, D. M. Mitrea, D. W. Sanders, M.-T. Wei, R. W. Kriwacki, C. P. Brangwynne

This study shows that heterotypic interactions drive nucleolar phase separation without a fixed saturation concentration, revealing a thermodynamic framework for condensate composition and function.

bioRxiv · Oct 22, 2019Biophysics