C. P. Brangwynne

The paper investigates interfacial mechanics of biomolecular condensates, finding critical-like behaviors such as reduced surface tension and bending elasticity near phase boundaries.

This study shows that increasing the oligomerization state of intrinsically disordered proteins enhances immiscibility and multiphase formation in biomolecular condensates.

This paper introduces VECTOR, a method using light-inducible condensates to reposition DNA loci and measure chromatin viscoelasticity.

The paper derives an analytical expression for condensate exchange timescales and shows interface resistance can arise from molecular bouncing at the droplet interface.

The paper investigates condensate size distributions in cells and finds that exponential and power-law distributions arise from different physical mechanisms, with the latter linked to a 'rich get richer' effect.

The paper maps nucleolar rRNA dynamics using imaging and modeling, finding that rRNA moves radially due to viscoelastic properties and polymerization, leading to a new model for rRNA release.

The paper uses proteomics to show that mesoscale biomolecular condensates organize 18% of the proteome in eukaryotic cytoplasm, revealing widespread dynamic clustering at ~100 nm.

This study uses simulations to show how sequence properties influence phase separation or aggregation in disordered proteins, identifying a charge-based parameter that predicts phase behavior.

The paper investigates how chromatin mechanics suppress phase separation in the nucleus and control droplet properties through theory and simulation.

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

This study shows HP1α crosslinks chromatin to maintain nuclear and mitotic chromosome mechanics, independent of histone methylation.

This study shows that importin-mediated interactions inhibit TPX2 phase separation, thereby regulating branching microtubule nucleation during spindle assembly.

The paper shows Polycomb proteins form condensates that induce chromatin compaction, but phase separation is not required for maintaining the compacted state, linking phase separation to epigenetic memory.

This study shows that chromatin mechanics slow down condensate coarsening by inhibiting droplet growth and causing subdiffusion, with implications for biophysical regulation of condensates.

This study investigates phase separation in disordered proteins using a coarse-grained model, revealing rich phase behavior influenced by hydrophobicity and sequence arrangement.

This study shows that heterotypic interactions drive nucleolar phase separation without a fixed saturation concentration, revealing a thermodynamic framework for condensate composition and function.

This study shows that TAF15 phase separation is enhanced by interactions with RNA Pol II CTD, lowering the energetic barrier for condensate formation and amplifying gene expression.

This study maps intracellular phase separation behavior using an optogenetic system, showing localized phase separation can occur through diffusive capture of protein ligands.