Large-scale design and refinement of stable proteins using sequence-only models
J. M. Singer, S. Novotney, D. Strickland, H. K. Haddox, N. Leiby, G. J. Rocklin, C. M. Chow, A. Roy, A. K. Bera, F. C. Motta, L. Cao, E.-M. Strauch, T. M. Chidyausiku, A. Ford, E. Ho, , E. Klavins
The paper presents two neural network models for predicting and generating stable proteins based on amino acid sequences, showing improved stability in both expert-designed and model-generated proteins.
bioRxiv · Mar 12, 2021Biophysics