Author

J. M. Singer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

A. J. Lutkewitte· 4 shared B. N. Finck· 3 shared G. J. Patti· 3 shared D. Ferguson· 2 shared G. I. Smith· 2 shared K. Cho· 2 shared M. R. Martino· 2 shared N. K. H. Yiew· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersPhysiology

A. J. Lutkewitte

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Author profile →

5 papers

Recent·Most cited

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

N. K. H. Yiew, D. Ferguson, K. Cho, S. Deja, C. Jarasvaraparn, M. Jacome-Sosa, A. J. Lutkewitte, S. Mukherjee, X. Fu, J. M. Singer, G. J. Patti, S. C. Burgess, B. N. Finck

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

bioRxiv · Feb 17, 2023 · PreprintPhysiology

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.

A. LaPoint, J. M. Singer, D. Ferguson, T. M. Shew, K. RenKemeyer, H. Palacios, R. Field, M. Shankaran, G. I. Smith, J. Yoshino, M. He, G. J. Patti, M. Hellerstein, S. Klein, J. R. Brestoff, , A. J. Lutkewitte

The paper shows that lower adipose lipin 1 in humans correlates with metabolic issues, and mice lacking adipocyte lipin 1 develop metabolic disorders.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

M. R. Martino, M. Gutierrez-Aguilar, N. K. H. Yiew, A. J. Lutkewitte, J. M. Singer, K. S. McCommis, G. I. Smith, K. Cho, J. A. Fletcher, S. Klein, G. J. Patti, S. C. Burgess, B. N. Finck

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Cell Reports · Apr 1, 2022Peer-reviewedPhysiology

Large-scale design and refinement of stable proteins using sequence-only models

J. M. Singer, S. Novotney, D. Strickland, H. K. Haddox, N. Leiby, G. J. Rocklin, C. M. Chow, A. Roy, A. K. Bera, F. C. Motta, L. Cao, E.-M. Strauch, T. M. Chidyausiku, A. Ford, E. Ho, , E. Klavins

The paper presents two neural network models for predicting and generating stable proteins based on amino acid sequences, showing improved stability in both expert-designed and model-generated proteins.

bioRxiv · Mar 12, 2021Biophysics

Antisense oligonucleotides against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1

A. J. Lutkewitte, J. M. Singer, T. M. Shew, M. R. Martino, A. M. Hall, B. N. Finck

This study shows that Mogat1 ASOs improve glucose metabolism in mice independently of Mogat1 knockdown or IFNAR-1 activation.

bioRxiv · Aug 5, 2020Physiology