Author

E.-M. Strauch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Assay:protein structure· 3 Research Focus:protein design· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Baker· 2 shared K. J. Gonzalez· 2 shared A. Eletsky· 1 shared A. Ford· 1 shared A. K. Bera· 1 shared A. Roy· 1 shared A. Tobin· 1 shared C. M. Chow· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

D. Baker

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4 papers

Recent·Most cited

Systematic computer-aided disulfide design as a general strategy to stabilize prefusion class I fusion proteins

K. J. Gonzalez, K. Yim, J. C. Blanco, M. S. Boukhvalova, E.-M. Strauch

This paper develops a computational method to identify stabilizing disulfide bonds for prefusion class I fusion proteins, demonstrating its effectiveness in stabilizing the RSV F protein and providing protection in a cotton rat model.

bioRxiv · Feb 29, 2024Bioengineering

Large-scale design and refinement of stable proteins using sequence-only models

J. M. Singer, S. Novotney, D. Strickland, H. K. Haddox, N. Leiby, G. J. Rocklin, C. M. Chow, A. Roy, A. K. Bera, F. C. Motta, L. Cao, E.-M. Strauch, T. M. Chidyausiku, A. Ford, E. Ho, , E. Klavins

The paper presents two neural network models for predicting and generating stable proteins based on amino acid sequences, showing improved stability in both expert-designed and model-generated proteins.

bioRxiv · Mar 12, 2021Biophysics

Sampling of Structure and Sequence Space of Small Protein Folds

T. W. Linsky, K. Noble, A. Tobin, R. Crow, L. P. Carter, J. L. Urbauer, D. Baker, E.-M. Strauch

The paper designs and evaluates 30,000 de novo proteins to explore shape diversity, identifies 6,200 stable proteins, and develops a classifier for stability prediction.

bioRxiv · Mar 10, 2021Bioengineering

Skp1 Dimerization Conceals its F-box Protein Binding Site

H. W. Kim, A. Eletsky, K. J. Gonzalez, H. van der Wel, E.-M. Strauch, J. H. Prestegard, C. M. West

This paper investigates how Skp1 dimerization hides its F-box protein binding site, showing that a mutation disrupts dimerization and allows Skp1 to bind F-box proteins.

bioRxiv · Jan 26, 2020Biochemistry