Author

D. T. Lac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5

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Research Focus:development & morphogenesis· 5 Approach:experimental assay· 5 Organism:yeast· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

G. O. Bozdag· 5 shared W. C. Ratcliff· 4 shared K. Tong· 3 shared A. J. Burnetti· 2 shared P. C. Kahn· 2 shared P. J. Yunker· 2 shared P. L. Conlin· 2 shared R. Pineau· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersEvolutionary Biology

G. O. Bozdag

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5 papers

Recent·Most cited

Whole-genome duplication in the Multicellularity Long Term Evolution Experiment

K. Tong, S. Datta, V. Cheng, D. J. Haas, S. Gourisetti, H. L. Yopp, T. C. Day, D. T. Lac, P. L. Conlin, G. O. Bozdag, W. C. Ratcliff

This study shows that diploid yeast under selection for larger multicellular size rapidly undergoes spontaneous whole-genome duplication, which persists and facilitates adaptation through increased genetic variation.

bioRxiv · Apr 18, 2024 · PreprintEvolutionary Biology

Experimental evolution of multicellularity via cuboidal cell packing in fission yeast

R. Pineau, P. C. Kahn, D. T. Lac, M. Denning, W. Wong, W. Ratcliff, G. O. Bozdag

This study experimentally evolves cuboidal cell packing in fission yeast, showing it leads to multicellular clusters with heritable group size and responses to group-level selection.

bioRxiv · Nov 3, 2023Evolutionary Biology

Proteostatic tuning underpins the evolution of novel multicellular traits

K. Montrose, D. T. Lac, A. J. Burnetti, K. Tong, G. O. Bozdag, M. Hukkanen, W. C. Ratcliff, J. Saarikangas

The paper shows that downregulation of Hsp90 drives cellular elongation and multicellular adaptation in the MuLTEE experiment, revealing a proteostatic mechanism for macroscopic multicellularity evolution.

bioRxiv · May 31, 2023 · PreprintEvolutionary Biology

Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment

R. Pineau, D. Demory, E. Libby, D. T. Lac, T. Day, P. Bravo, J. Weitz, P. J. Yunker, G. O. Bozdag, W. C. Ratcliff

This study shows how multicellularity evolves through niche partitioning and adaptive divergence in snowflake yeast, leading to stable coexistence via a trade-off between size and competitiveness for oxygen.

bioRxiv · Jan 19, 2023Evolutionary Biology

De novo evolution of macroscopic multicellularity

G. O. Bozdag, S. A. Zamani-Dahaj, T. C. Day, P. C. Kahn, A. J. Burnetti, D. T. Lac, K. Tong, P. L. Conlin, A. H. Balwani, E. L. Dyer, P. J. Yunker, W. C. Ratcliff

This study shows how snowflake yeast evolved macroscopic multicellularity under anaerobic conditions through biophysical adaptations, while remaining microscopic under low oxygen conditions.

bioRxiv · Aug 3, 2021 · PreprintEvolutionary Biology