Author

K. Tong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Cell Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 1

Frequent Co-Authors

D. T. Lac· 3 shared G. O. Bozdag· 3 shared W. C. Ratcliff· 3 shared A. J. Burnetti· 2 shared A. Mengotto· 2 shared C. Florez· 2 shared D. Haslwanter· 2 shared E. Laudermilch· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersEvolutionary Biology

D. T. Lac

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Whole-genome duplication in the Multicellularity Long Term Evolution Experiment

K. Tong, S. Datta, V. Cheng, D. J. Haas, S. Gourisetti, H. L. Yopp, T. C. Day, D. T. Lac, P. L. Conlin, G. O. Bozdag, W. C. Ratcliff

This study shows that diploid yeast under selection for larger multicellular size rapidly undergoes spontaneous whole-genome duplication, which persists and facilitates adaptation through increased genetic variation.

bioRxiv · Apr 18, 2024 · PreprintEvolutionary Biology

Proteostatic tuning underpins the evolution of novel multicellular traits

K. Montrose, D. T. Lac, A. J. Burnetti, K. Tong, G. O. Bozdag, M. Hukkanen, W. C. Ratcliff, J. Saarikangas

The paper shows that downregulation of Hsp90 drives cellular elongation and multicellular adaptation in the MuLTEE experiment, revealing a proteostatic mechanism for macroscopic multicellularity evolution.

bioRxiv · May 31, 2023 · PreprintEvolutionary Biology

Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity

J. Paukstyte, R. M. Lopez Cabezas, Y. Feng, K. Tong, D. Schnyder, E. Elomaa, P. Gregorova, M. Doudin, M. Sarkka, J. Sarameri, A. Lippi, H. Vihinen, J. Juutila, A. Nieminen, P. Toronen, , J. Saarikangas

The paper identifies age-related protein structural changes in yeast and shows that inhibiting polymerization of glutamate synthase extends lifespan.

bioRxiv · Jan 23, 2023Cell Biology

De novo evolution of macroscopic multicellularity

G. O. Bozdag, S. A. Zamani-Dahaj, T. C. Day, P. C. Kahn, A. J. Burnetti, D. T. Lac, K. Tong, P. L. Conlin, A. H. Balwani, E. L. Dyer, P. J. Yunker, W. C. Ratcliff

This study shows how snowflake yeast evolved macroscopic multicellularity under anaerobic conditions through biophysical adaptations, while remaining microscopic under low oxygen conditions.

bioRxiv · Aug 3, 2021 · PreprintEvolutionary Biology

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

D. Haslwanter, M. E. Dieterle, A. Z. Wec, C. M. O'Brien, M. Sakharkar, C. Florez, K. Tong, C. G. Rappazzo, G. Lasso, O. Vergnolle, A. S. Wirchnianski, R. H. Bortz, E. Laudermilch, J. M. Fels, A. Mengotto, , R. K. Jangra

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

bioRxiv · Jun 10, 2021Microbiology

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

N. G. Herrera, N. C. Morano, A. Celikgil, G. I. Georgiev, R. J. Malonis, J. H. Lee, K. Tong, O. Vergnolle, A. B. Massimi, L. Y. Yen, A. J. Noble, M. Kopylov, J. B. Bonanno, S. C. Garrett-Thomson, D. B. Hayes, , S. C. Almo

This study evaluates the production, characterization, and antigenicity of SARS-CoV-2 S protein constructs in two cell lines, showing high-quality yields and consistent behavior across assays.

bioRxiv · Jun 14, 2020Biochemistry

Polarized endosome dynamics engage cytosolic Par-3 and dynein during asymmetric division

X. Zhao, K. Tong, x. Chen, B. Yang, Q. Li, Z. Dai, X. Shi, I. Seiple, B. Huang, S. Guo

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.

bioRxiv · May 15, 2020Cell Biology

Negative plant-microbiome feedback limits productivity in aquaponics

J. A. Day, A. E. Otwell, C. Diener, K. E. Tams, B. M. Bebout, A. M. Detweiler, M. D. Lee, M. T. Scott, W. Ta, M. Ha, S. A. Carreon, K. Tong, A. A. Ali, S. M. Gibbons, N. S. Baliga

This study shows that transferring established microbiomes to aquaponic systems reduces lettuce growth due to pathogen enrichment, highlighting negative feedback mechanisms similar to soil ecology.

bioRxiv · Aug 28, 2019 · PreprintMicrobiology