Missense mutations in the calcium-activated chloride channel TMEM16A promote tumor growth by activating oncogenic signaling in Human Cancer.
S. Cruz-Rangel, J. J. De Jesus-Perez, A. Gopalkrishnan, R. Gomez-Casal, J. Pacheco, M. R. Brown, A. Yassin-Kassab, G. R. Hammond, C. A. Bertrand, J. Arreola, K. Kiselyov, D. Umamaheswar
This paper investigates TMEM16A missense mutations in cancer, finding they promote tumor growth through altered signaling, independent of chloride flux.
bioRxiv · Jun 21, 2023 · PreprintCancer Biology