Targeting ATP12A, a non-gastric proton pump alpha subunit, for idiopathic pulmonary fibrosis treatment
M. Abdelgied, K. Uhl, O. G. Chen, C. Schultz, K. Tripp, A. M. Peraino, S. Paithankar, B. Chen, M. T. Kakazu, A. C. Bahena, T. E. Jager, C. Lawson, D. W. Chesla, N. Pestov, N. N. Modyanov, , X. Li
This study identifies ATP12A as a potential therapeutic target for idiopathic pulmonary fibrosis by showing its overexpression in IPF lungs and its role in worsening fibrosis in mice.
bioRxiv · Jun 8, 2022Cell Biology