M. Adams

Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19

The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.

Structural Insights into The Role of MAGEA4 in RAD18 Regulation: Implications for Ubiquitin Ligase-Binding across the MAGE Protein Family

This study identifies the interaction between MAGEA4 and RAD18 using NMR and AlphaFold2, revealing structural insights into how MAGEA4 regulates RAD18's ubiquitination activity and its implications for cancer.

Undergraduates' reactions to errors mediates the association between growth mindset and study strategies

This study examines how undergraduates' reactions to errors mediate the link between growth mindset and study strategies, finding that growth mindset influences adaptive error responses, which in turn promote effective study practices.

Long-term climatic stability drives accumulation and maintenance of divergent lineages in a temperate biodiversity hotspot

The paper assesses how long-term climatic stability has influenced lineage accumulation and persistence in a freshwater fish group in a biodiversity hotspot, finding that climatic stability allowed isolation but future climate change may threaten these lineages.

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces

The paper studies genetic and phenotypic diversity across 1,800 Saccharomyces strains, revealing insights into macroevolutionary processes and gene flow effects on traits.

Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer

This paper shows that combining PI3K and MLL1 inhibition enhances anti-tumor effects in HR+ breast cancer by disrupting a feedback loop between MLL1 and AKT.

Structural basis for protein glutamylation by the Legionella pseudokinase SidJ

This study determines the cryo-EM structure of SidJ in complex with SdeA, revealing its mechanism of glutamylation and substrate recognition.

A high-content screen profiles cytotoxic microRNAs in pediatric and adult glioblastoma cells and identifies miR-1300 as a potent inducer of cytokinesis failure

This study identifies miR-1300 as a potent cytotoxic microRNA in glioblastoma cells, causing cytokinesis failure and apoptosis, with potential therapeutic applications.

Integrated epigenome, exome and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids.

This study integrates epigenome, exome, and transcriptome data to identify molecular subtypes and homeotic transformation in uterine fibroids.