POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer
Wungki Park, Shigeaki Umeda, Marc Hilmi, Catherine Anne O'Connor, Roshan Sharma, Nuray Tezcan, Haochen Zhang, Yingjie Zhu, Carly Schwartz, Amin Yaqubie, Anna M. Varghese, Kevin Soares, Vaia Florou, DaeWon Kim, Steven Brad Maron, , Eileen Mary O'Reilly
The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.
bioRxiv · Mar 17, 2026 · PreprintCancer Biology