Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity
Riku Kawanabe-Kobayashi, Sawako Uchiyama, Kohei Yoshihara, Keisuke Koga, Daiki Kojima, Thomas John McHugh, Izuho Hatada, Ko Matsui, Kenji F. Tanaka, Makoto Tsuda
The paper identifies a stress-induced pain circuit involving locus coeruleus noradrenergic neurons and spinal astrocytes in mice, showing their role in mechanical pain hypersensitivity.
eLife · Mar 9, 2026Peer-reviewedNeuroscience