Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity
Riku Kawanabe-Kobayashi, Sawako Uchiyama, Kohei Yoshihara…·Makoto Tsuda
The paper identifies a stress-induced pain circuit involving locus coeruleus noradrenergic neurons and spinal astrocytes in mice, showing their role in mechanical pain hypersensitivity.