Severe malarial anaemia is associated with parasite enrichment and host alterations in the bone marrow
Joao da Silva Filho, Elamaran Meibalan, Himanshu Gupta, Dario Beraldi, Selina E. R. Bopp, Dyann F. Wirth, Christopher A. Moxon, Eusébio Macete, Cinta Moraleda, Ruth Aguilar, Alfredo G. Mayor, Dan Milner, Clara Menéndez, Matthias Marti
This study shows that severe malarial anaemia is linked to increased red blood cell production, iron metabolism, tissue injury, and parasite biomass in bone marrow, with better resolution from bone marrow analysis than peripheral blood.
bioRxiv · Apr 29, 2026 · PreprintMicrobiology