Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-L-methionine
Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert Blumenthal, Rong Huang, Xiaodong Cheng
This study identifies SAM analogs that inhibit specific methyltransferases in pathogens and humans, offering potential antivirulence agents and chemical probes.
ACS Omega · Nov 17, 2025Peer-reviewedBiochemistry