Jiankui He

This study sequences the M13 virus genome using a new single molecule sequencing platform with 100% coverage and consensus sequence accuracy.

This study uses single molecule sequencing of cell-free DNA from maternal plasma to detect trisomy 13, 18, and 21 with improved sensitivity and reduced GC bias compared to NGS.

This study develops a method to improve ctDNA detection in lung cancer by comparing mutations in tumor tissue and blood, showing higher sensitivity than traditional biomarkers.

The paper resequences the E. coli genome using the GenoCare single molecule sequencing platform and shows comparable performance to the Illumina MiSeq system.

This study profiles somatic mutations in cfDNA and white blood cells from 1134 healthy individuals to understand mutation patterns and origins in cfDNA.

This paper introduces a single molecule targeted sequencing technology for cancer gene mutation detection that reduces sample preparation and avoids PCR biases.

This study compares three single-cell DNA amplification methods in hippocampal neurons, finding MALBAC and WGA4 to be highly reproducible with high success rates and ability to detect copy number variations.

This study compares three single-cell DNA amplification methods in hippocampal neurons, finding MALBAC and WGA4 to be highly reproducible with high success rates and ability to detect copy number variations.