Author

Robert Blumenthal

University of ToledoORCID 0000-0002-0873-0724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Jujun ZhouiD· 4 shared Xiaodong ChengiD· 4 shared John R. HortoniD· 3 shared Abhinav K. JainiD· 2 shared Meigen YuiD· 2 shared Antonello MaiiD· 1 shared Bigang Liu· 1 shared Caleb ChangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiochemistry

Jujun ZhouORCID

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Author profile →

4 papers

Recent·Most cited

Bipartite DNA binding domain of transcription factor BCL11B binds clustered short DNA sequence motifs

Jisun Lee, Jujun Zhou, John R. Horton, Meigen Yu, Munachi Daniella Muoghalu, Faizan Ahmed Khan, Xiaotian Zhang, Yun Huang, Robert Blumenthal, Xiaodong Cheng

This paper investigates the DNA-binding properties of BCL11B's bipartite zinc finger domain and its mutations linked to neurodevelopmental disorders.

bioRxiv · May 2, 2026 · PreprintBiochemistry

Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cells

Meigen Yu, Puspa Das, John R. Horton, Jujun Zhou, J. Jack Lee, Tingting Hong, Yue Lu, Marcos R. Estecio, Polina A. Iakova, Abhinav K. Jain, Gianluca Sbardella, Yan Xiong, Jian Jin, Robert Blumenthal, Yun Huang, , Xiaodong Cheng

This study investigates BCL11A DNA binding mechanisms, epigenetic regulation, and small-molecule effects on its expression in human erythrocyte precursor cells.

bioRxiv · Feb 9, 2026 · PreprintBiochemistry

Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-L-methionine

Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert Blumenthal, Rong Huang, Xiaodong Cheng

This study identifies SAM analogs that inhibit specific methyltransferases in pathogens and humans, offering potential antivirulence agents and chemical probes.

ACS Omega · Nov 17, 2025Peer-reviewedBiochemistry

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R. Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K. Jain, Xing Zhang, Robert Blumenthal, Taiping Chen, , Xiaodong Cheng

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

Cell chemical biology · Oct 21, 2024Peer-reviewedMolecular Biology