Dan Yu

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Over 8,000 gapless human centromeres reveal population-stratified satellite-array, inversion and haplotype variation, multiple candidate kinetochore sites in 16.8% of centromeres, and single-base substitution rates comparable to flanking pericentromeres.

The paper introduces ASMaid, a method to detect archaic introgression sequences in human genomes, revealing more complete and diverse archaic segments than previous methods.

The paper identifies conserved regulatory programs in placental invasion across mammals and links their dysregulation to pregnancy disorders and cancers.

This paper introduces a language model for 5' UTRs that improves predictions of translation efficiency and mRNA expression, and validates novel 5' UTR designs through wet-lab experiments.