FAIM Inhibits Insulin Amyloidogenesis through a Noncanonical Aggregation Pathway
Dana Wolfe, Jhinuk Saha, Joshua Mitchell, Samuel D. McCalpin, Michael Gutknecht, Prof. Charles L. Brooks, Thomas L. Rothstein, Ayyalusamy Ramamoorthy
This paper identifies FAIM as an endogenous inhibitor of insulin amyloid formation by redirecting insulin toward non-toxic assemblies and reducing {beta}-sheet formation.
bioRxiv · Jul 14, 2026 · PreprintBiochemistry