Samuel D. McCalpin

Saponin Chemistry Controls Anionic Lipid Tolerance and Divalent Metal Ion Responses in Magnetically Alignable Bicelles

This study investigates how saponin chemistry affects bicelle properties like anionic lipid tolerance and divalent metal ion stability, identifying design principles for better membrane-mimetic systems.

FAIM Inhibits Insulin Amyloidogenesis through a Noncanonical Aggregation Pathway

This paper identifies FAIM as an endogenous inhibitor of insulin amyloid formation by redirecting insulin toward non-toxic assemblies and reducing {beta}-sheet formation.

Anionic lipid catalyzes the generation of cytotoxic insulin oligomers

This study shows that anionic lipids like DMPG influence insulin aggregation pathways and intermediate formation, with soluble intermediates being more cytotoxic than fibrils.

Differential Effects of Ganglioside Lipids on the Conformation and Aggregation of Islet Amyloid Polypeptide

This study investigates how different gangliosides affect hIAPP aggregation and structure, finding that lipid-peptide ratios and charge/headgroup size influence aggregation and conformation.