Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue
Roeland J.W. Middelbeek, Jiekun Yang, Pasquale Nigro, Benjamin T. James, Danae Papadopoulos, Laura K. Simpson, Jeu Park, Maria T. Vamvini, Li‐Lun Ho, Hui Zhang, Nicholas P. Carbone, Michael F. Hirshman, M Kellis, Laurie J. Goodyear
This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.
bioRxiv · Oct 11, 2025 · PreprintMolecular Biology