Li‐Lun Ho

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

The paper identifies a mature dendritic cell subtype associated with improved immune response and prognosis in melanoma patients treated with anti-PD-1 checkpoint inhibitors.

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

The paper analyzes intercellular communication in brown adipose tissue using single-cell transcriptomics and identifies temperature-regulated signaling interactions.

The paper investigates how genome plasticity and transcriptional organization enable metabolic resilience to nutrient limitation and fasting endurance.

The paper identifies a new source of cold-induced brown adipocytes, specifically vascular smooth muscle-derived progenitors expressing TRPV1.