Laurie J. Goodyear

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance Training

This study identifies shared and sex-specific molecular responses to endurance training in skeletal muscle using multi-omics data from rats.

The Long Non-coding RNA Landscape of Endurance Exercise Training

This study identifies tissue-specific lncRNA responses to endurance exercise in rats, revealing sex differences and potential therapeutic implications.

Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC

The paper profiles multi-omic changes in abdominal subcutaneous adipose tissue after acute exercise in sedentary adults, identifying distinct molecular programs and candidate exerkines.

Maternal exercise alters placental proteome in an exercise mode-specific manner

This study shows that different maternal exercise modes alter the placental proteome uniquely, with ~20% of placental proteins linked to exercise volume during pregnancy.

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

Effects of maternal exercise modes on infant cord blood proteome

This study shows that different maternal exercise modes alter the infant cord blood proteome, with 61 downregulated proteins common across all exercise types.

Exercise training remodels inter-organ endocrine networks

Correlation-based endocrine network analysis of MoTrPAC rat multi-tissue omics shows 8-week endurance training reshapes inter-organ secretory crosstalk, centering subcutaneous adipose, extracellular matrix factors, and Wnt regulators.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

This study profiles multi-omic changes in multiple tissues of rats during endurance exercise training, identifying molecular adaptations and sex-specific responses across time.

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.