Author

Pasquale Nigro

Joslin Diabetes CenterORCID 0000-0002-2918-8356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1

Frequent Co-Authors

Laurie J. GoodyeariD· 3 shared Michael F. HirshmaniD· 3 shared Nicholas P. CarboneiD· 3 shared Maria T. VamviniiD· 2 shared Albina Tskhay· 1 shared Alec EamesiD· 1 shared Alexander Raskind· 1 shared Alexander TyshkovskiyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Laurie J. GoodyearORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 30, 2026

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

Alibek Moldakozhayev, Alexander Tyshkovskiy, Pasquale Nigro…·Vadim N. Gladyshev

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

DOI 10.64898/2025.12.28.696721

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintOct 11, 2025

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue

Roeland J.W. Middelbeek, Jiekun Yang, Pasquale Nigro…·Laurie J. Goodyear

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

DOI 10.1101/2025.10.11.681273

humanbulk RNA-seq

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Molecular BiologyNature MetabolismPeer-reviewedMay 1, 2024

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

Gina M. Many, James A. Sanford, Tyler J. Sagendorf…·Russell P. Tracy

This study examines how endurance exercise training affects rat subcutaneous white adipose tissue, revealing sex-specific molecular responses and differences in adiposity and metabolism.

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ratbulk RNA-seq

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