Author

Roeland J.W. Middelbeek

Joslin Diabetes CenterORCID 0000-0003-3862-8082Unclaimed ORCID profile · follow to get notified of new preprints

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Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Approach:statistical model· 1

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Benjamin T. JamesiD· 1 shared Danae Papadopoulos· 1 shared Hui Zhang· 1 shared Jeu ParkiD· 1 shared Jiekun YangiD· 1 shared Laura K. Simpson· 1 shared Laurie J. GoodyeariD· 1 shared Li‐Lun Ho· 1 shared

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Benjamin T. JamesORCID

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1 paper

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Molecular BiologybioRxivPreprintOct 11, 2025

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue

Roeland J.W. Middelbeek, Jiekun Yang, Pasquale Nigro…·Laurie J. Goodyear

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

DOI 10.1101/2025.10.11.681273

humanbulk RNA-seq

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