Iron-endoplasmic reticulum-extracellular matrix axis regulates cancer cell invasion
Arun Asif, Kavya Panjwani, Kavya Nair, Percy Smith, Dancan Oruko, Isaiah Crosbourne, Joseph DeLuca, Taylor Humphrey, Ramon Bossardi Ramos, David T. Corr, Teresita Padilla‐Benavides, Margarida Barroso
This study shows that loss of DMT1 disrupts iron homeostasis, leading to ER stress and ECM destabilization, which enhances cancer cell invasion in 3D models.
bioRxiv · Aug 3, 2026 · PreprintCancer Biology