Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation
Maria Elisa Caetano‐Silva, Akriti Shrestha, Audrey F. Duff, Danica Kontic, Patricia C. Brewster, Mikaela C. Kasperek, Chia‐Hao Lin, Derek A. Wainwright, Diego Hernández‐Saavedra, Jeffrey A. Woods, Michael T. Bailey, Thomas W. Buford, Jacob M. Allen
This study shows that aging alters gut microbiota immunogenicity, increasing TLR4 activation and inflammation, and that these changes are linked to heightened host inflammation.
Aging Cell · May 9, 2024Peer-reviewedImmunology