Author

Derek A. Wainwright

Loyola University ChicagoORCID 0000-0001-7232-4264Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Jacob M. AlleniD· 2 shared Akriti ShresthaiD· 1 shared Ali Vaziri GohariD· 1 shared Arabela A. GrigorescuiD· 1 shared Audrey F. DuffiD· 1 shared Bakhtiar YaminiiD· 1 shared Chia‐Hao LiniD· 1 shared Danica Kontic· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Jacob M. AllenORCID

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2 papers

Recent·Most cited

Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)

Paige J. Monsen, Prashant V. Bommi, Arabela A. Grigorescu, Kristen L. Lauing, Yingyu Mao, Payton Berardi, Lijie Zhai, Ohiowele Ojo, Manon Penco-Campillo, Taylor Koch, Michael Egozi, Sonam Jha, Sara F. Dunne, Hong Jiang, Guiqin Song, , Gary E. Schiltz

This study optimizes a PROTAC to degrade IDO1 with high potency in GBM cells, showing sustained degradation via the ubiquitin-proteasome system.

Journal of Medicinal Chemistry · Feb 13, 2025Peer-reviewedBiochemistry

Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation

Maria Elisa Caetano‐Silva, Akriti Shrestha, Audrey F. Duff, Danica Kontic, Patricia C. Brewster, Mikaela C. Kasperek, Chia‐Hao Lin, Derek A. Wainwright, Diego Hernández‐Saavedra, Jeffrey A. Woods, Michael T. Bailey, Thomas W. Buford, Jacob M. Allen

This study shows that aging alters gut microbiota immunogenicity, increasing TLR4 activation and inflammation, and that these changes are linked to heightened host inflammation.

Aging Cell · May 9, 2024Peer-reviewedImmunology