Principles of in situ protein sequencing: expansion microscopy-adapted Edman degradation and amino acid recognition
Camille Marie Mitchell, Sara Z. Tavana, Joanne Peng, Hao Wang, Jiuhan Shi, Chi Zhang, Lilia Evgeniou, Masy Domecillo, Shiwei Wang, Daniel Estandian, Alexi G. Choueiri, E. Wong, Sarah Dohadwala, Isken Kenzhebaev, Tay Won Shin, , Edward S. Boyden
This study adapts Edman degradation and amino acid recognition to expansion microscopy gels to demonstrate in situ protein sequencing principles using synthetic constructs.
bioRxiv · Jul 21, 2026 · PreprintBiochemistry