Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson's disease
Desirée Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Péter István Kulcsár, Simon d‘Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwank
This study uses base editing to downregulate PTBP1 in neurons of a PD mouse model, rescuing motor symptoms without affecting astrocytes.
eLife · Dec 13, 2024Peer-reviewedNeuroscience