Jonas Mumenthaler

Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model for Parkinson's disease

This study uses base editing to downregulate PTBP1 in neurons of a PD mouse model, rescuing motor symptoms without affecting astrocytes.

Prime editing of the beta-1 adrenoceptor in the brain reprograms mouse behavior

This study uses prime editing in mice brains to introduce a mutation in the Adrb1 gene, leading to increased activity and exploratory behavior.