Human NLRP1 and NLRP3 interact driving inflammation in inflammosomopathies and inflammatory diseases
Juan Miguel Suarez-Rivero, Inés Muela‐Zarzuela, Antonio Astorga-Gamaza, Rosa Antón, Sofia Bali, Joaquin Tamargo‐Azpilicueta, Alejandra Guerra‐Castellano, Raquel de la Varga‐Martínez, Daniel García-Cuesta, Irene Díaz‐Moreno, Łukasz A. Joachimiak, Javier Oroz, Alberto Sanz, Mario David Cordero
This study identifies a hybrid inflammasome formed by NLRP1 and NLRP3 in human cells, associated with inflammation in inflammasomopathies and transplant patients.
bioRxiv · Jan 29, 2026 · PreprintImmunology