Author

Inés Muela‐Zarzuela

Universidad Pablo de OlavideORCID 0000-0002-7240-8334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Mario David CorderoiD· 3 shared Antonio Astorga-GamazaiD· 2 shared Juan Miguel Suarez-RiveroiD· 2 shared Alberto SanziD· 1 shared Alejandra Guerra‐CastellanoiD· 1 shared Alessandra TammaroiD· 1 shared Alexis VariniD· 1 shared Andrei SeluanoviD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

Mario David CorderoORCID

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3 papers

Recent·Most cited

cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation

John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner, Lucinda Fitzgibbons, Natasha Sieczkiewicz, Xiaoyan Liao, Weijie He, Sung Jae Bae, Michael E. Meadow, Eric C. Hillpot, Joseph Cutting, Victoria Paige, Max Zacher, Seyed Ali Biashad, Matthew A. Simon, , Vera A. Gorbunova

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

Nature Aging · Aug 25, 2026Peer-reviewedCell Biology

Human NLRP1 and NLRP3 interact driving inflammation in inflammosomopathies and inflammatory diseases

Juan Miguel Suarez-Rivero, Inés Muela‐Zarzuela, Antonio Astorga-Gamaza, Rosa Antón, Sofia Bali, Joaquin Tamargo‐Azpilicueta, Alejandra Guerra‐Castellano, Raquel de la Varga‐Martínez, Daniel García-Cuesta, Irene Díaz‐Moreno, Łukasz A. Joachimiak, Javier Oroz, Alberto Sanz, Mario David Cordero

This study identifies a hybrid inflammasome formed by NLRP1 and NLRP3 in human cells, associated with inflammation in inflammasomopathies and transplant patients.

bioRxiv · Jan 29, 2026 · PreprintImmunology

Inflammasome Profiling in Human Natural Killer Cells under Pro-inflammatory Stimuli and Solid Organ Transplantation

Antonio Astorga-Gamaza, Inés Muela‐Zarzuela, Juan Miguel Suarez-Rivero, Alexis Varin, Maarten Naesens, Alessandra Tammaro, Jesper Kers, Juan López-Pérez, Raquel de la Varga-Martínez, Auxiliadora Mazuecos, Baptiste Lamarthée, Mario D. Cordero

This study shows human NK cells can activate inflammasomes in vitro and in transplant patients, with distinct responses in CD56 subsets and sustained activation in renal dysfunction and transplant rejection.

bioRxiv · Apr 17, 2024 · PreprintImmunology