Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin/F-actin based oscillatory ratchet mechanism
Ilkka Paatero, Loïc Sauteur, Minkyoung Lee, Anne K. Lagendijk, Daniel Heutschi, Dimitri Bieli, Benjamin M. Hogan, Markus Affolter, Heinz‐Georg Belting
The paper identifies junction-based lamellipodia (JBL) as structures driving endothelial cell movement during vascular remodeling, showing their dependence on F-actin and VE-cadherin.
bioRxiv · Nov 1, 2017 · PreprintDevelopmental Biology