Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity
Harry Fischl, Tamsin J. Samuels, Byron Andrews, Lina Vasiliauskaitė, Daniel Jupp, Claire J. Saunders, Joanna Obacz, Yaara Ofir-Rosenfeld, Oliver Rausch
This study shows that inhibiting METTL3 with STC-15 causes RNA misprocessing, leading to dsRNA formation and activation of innate immunity in cancer cells.
bioRxiv · Dec 9, 2025 · PreprintCancer Biology