Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum
Dylan Richards, Klebea Sohn, Shrikanth Chomanahalli Basavarajappa, Daniel M. Horowitz, Joshua James Rusbuldt, Lynn Tomsho, Kate Paget, Ivan Chavez, Koen Van den Berge, Bradford L. McRae, Heather Loughnane, Séamus Hussey, Patrick T. Walsh, Darren Ruane
This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.
Cell Reports · Jul 21, 2025Peer-reviewedImmunology