Author

Séamus Hussey

Children's Health Ireland at CrumlinORCID 0000-0002-9362-0465Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Darren RuaneiD· 2 shared Heather Loughnane· 2 shared Patrick T. WalshiD· 2 shared Shrikanth Chomanahalli BasavarajappaiD· 2 shared Anna Dominik· 1 shared Bradford L. McRae· 1 shared Conor M. FinlayiD· 1 shared Daniel M. Horowitz· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Darren RuaneORCID

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2 papers

Recent·Most cited

Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum.

Heather Loughnane, Shrikanth Chomanahalli Basavarajappa, Anna Dominik, Conor M. Finlay, Séamus Hussey, Darren Ruane, Patrick T. Walsh

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

Clinical & Experimental Immunology · Jan 1, 2026Peer-reviewedImmunology

Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum

Dylan Richards, Klebea Sohn, Shrikanth Chomanahalli Basavarajappa, Daniel M. Horowitz, Joshua James Rusbuldt, Lynn Tomsho, Kate Paget, Ivan Chavez, Koen Van den Berge, Bradford L. McRae, Heather Loughnane, Séamus Hussey, Patrick T. Walsh, Darren Ruane

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

Cell Reports · Jul 21, 2025Peer-reviewedImmunology