Darren Ruane

This study shows that IL-36Ra deficiency reduces CCL27 expression, leading to skin inflammation in DITRA patients and mice, and that restoring CCL27 mitigates inflammation.

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

The paper shows loss of HMGCS2-mediated ketogenesis in intestinal stem cells impairs mucosal healing in Ulcerative colitis and identifies {beta}HB as a potential therapeutic target.

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.