Shrikanth Chomanahalli Basavarajappa

This study shows that miR146a deficiency protects NOD mice from T1D by enhancing c-Rel-dependent Treg cell function through increased FOXP3 expression.

This study shows that IL-36Ra deficiency reduces CCL27 expression, leading to skin inflammation in DITRA patients and mice, and that restoring CCL27 mitigates inflammation.

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

This study identifies TF-mediated thrombogenicity in colitogenic CD4+ T cells and shows APC signalling reduces their procoagulant activity in IBD.