Patrick T. Walsh

Deficiency of IL-36 receptor antagonist (DITRA) is associated with decreased homoeostatic CCL27 expression leading to heightened dermal inflammation.

This study shows that IL-36Ra deficiency reduces CCL27 expression, leading to skin inflammation in DITRA patients and mice, and that restoring CCL27 mitigates inflammation.

Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum.

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling.

This study identifies TF-mediated thrombogenicity in colitogenic CD4+ T cells and shows APC signalling reduces their procoagulant activity in IBD.