Development of pyrazolopyrimidine based macrocyclic kinase inhibitors targeting AAK1
Theresa Elisabeth Mensing, Christian Georg Kurz, Jennifer Alisa Amrhein, Theresa A. L. Ehret, Franziska Preuß, Sebastian Mathea, Marwah Karim, Tran Do Hoang Nhu, Zuzana Kadlecová, Tuomas Aleksi Tolvanen, Daniel Martinez Molina, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
The paper develops pyrazolopyrimidine-based macrocyclic kinase inhibitors targeting AAK1, showing selectivity over related NAK family members and antiviral activity against RNA viruses.
European Journal of Medicinal Chemistry · Aug 22, 2025Peer-reviewedBiochemistry