Author

Shirit Einav

Chan Zuckerberg Biohub San FranciscoORCID 0000-0001-6441-4171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Marwah KarimiD· 3 shared Tran Do Hoang NhuiD· 3 shared Norma F NeffiD· 2 shared Sirle SauliD· 2 shared Stefan KnappiD· 2 shared Susanne MülleriD· 2 shared Theresa A. L. Ehret· 2 shared Thomas HankeiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Marwah KarimORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiochemistryEuropean Journal of Medicinal ChemistryPeer-reviewedAug 22, 2025

Development of pyrazolopyrimidine based macrocyclic kinase inhibitors targeting AAK1

Theresa Elisabeth Mensing, Christian Georg Kurz, Jennifer Alisa Amrhein…·Thomas Hanke

The paper develops pyrazolopyrimidine-based macrocyclic kinase inhibitors targeting AAK1, showing selectivity over related NAK family members and antiviral activity against RNA viruses.

4 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

GenomicsbioRxivPreprintAug 8, 2025

Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics

Alina Isakova, Daniel Dan Liu, Ivana Cvijović…·Stephen R. Quake

This paper introduces a method to capture non-coding RNAs in single-cell RNA-seq, revealing new insights into gene regulation in immune cells, infected hepatocytes, and brain development.

3 citations

humanscRNA-seq

𝕏 PostBluesky

MicrobiologyNature CommunicationsPeer-reviewedJul 10, 2025

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

Marwah Karim, Manjari Mishra, Chieh‐Wen Lo…·Shirit Einav

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

19 citationstop 1%

humanorganoid / primary culture

𝕏 PostBluesky

BiochemistryJournal of Medicinal ChemistryPeer-reviewedJul 19, 2024

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer…·Thomas Hanke

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

13 citations

humanexperimental assay

𝕏 PostBluesky