Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model
Simon J. McCluney, Danielle Park, Daniel S.J. Miller, Merima Mehić, Robert Bloxham, Emma de Vries, Xuelu Wang, Stefan Boeing, Luigi D’Antonio, Łukasz Wieteska, Gwen Pyeatt, Stephanie Strohbuecker, Probir Chakravarty, Taianá Maia de Oliveira, Robert W. Wilkinson, , Caroline S. Hill
This study shows anti-activin treatment reduces desmoplastic barriers and increases T cell infiltration in tumors, improving survival in SMAD4-null pancreatic cancer models.
bioRxiv · Jun 13, 2025 · PreprintCancer Biology