Stefan Boeing

This study shows TACI regulates MZ B cell development through the PI3K-AKT pathway and FOXO1 inhibition, not B cell survival.

This study shows that inhibiting Myc in pancreatic tumours triggers GM-CSF release, which drives tumour regression via cDC1s, offering a new therapeutic strategy for PDAC.

This study shows that targeting Myc in lung adenocarcinoma activates an immune programme that drives tumour regression through IL-33-mediated eosinophil recruitment.

The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.

This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.

This study shows anti-activin treatment reduces desmoplastic barriers and increases T cell infiltration in tumors, improving survival in SMAD4-null pancreatic cancer models.

This paper introduces cESFW for scRNA-seq analysis, revealing high-resolution developmental trajectories in human embryos and identifying lineage-specific markers.

This study identifies ARID3A as a regulator of intestinal epithelial cell proliferation and differentiation, showing its role in maintaining tissue homeostasis through modulation of TA cell dynamics.

The paper identifies a distinct transcriptional programme in pregranulosa cells before primordial follicle activation using single-cell RNA sequencing in mice.

The paper maps the regulatory landscape of neuronal and glial differentiation in the enteric nervous system using single-cell RNA sequencing and identifies gene modules and epigenetic memory associated with neurogenesis and gliogenesis.

The paper shows KLF17 can induce a naive-like transcriptome in primed hESCs but is not required for naive pluripotency establishment in vitro.

The paper identifies molecular markers and gene regulatory mechanisms for projection neuron subtypes in the mouse olfactory bulb using single nucleus and bulk RNA sequencing.

This study identifies transcriptional and chromatin changes during astrocyte maturation in vivo and in culture, showing that extrinsic signals regulate intrinsic transcription factors to drive maturation.

This study shows zebrafish enteric glia can proliferate and generate enteric neurons, similar to brain neural stem cells, and are regulated by Notch signaling.

The paper shows microbiota induce AhR in enteric neurons, enabling them to respond to environmental signals.