Caroline S. Hill

The coumarin derivative X6632 is a pan-ID protein inhibitor that suppresses tumor growth by targeting cancer cells and the tumor-associated microvasculature

Pro-domain-dependent folding and co-receptor-mediated targeting to optimize an antagonistic TGF-β monomer for gene-based delivery

This paper improves the folding and targeting of an engineered TGF-β monomer for gene-based delivery by modifying its pro-domain and adding a CD44 binding domain.

Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model

This study shows anti-activin treatment reduces desmoplastic barriers and increases T cell infiltration in tumors, improving survival in SMAD4-null pancreatic cancer models.

Structures of TGF-beta with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling

This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.

Nodal signaling establishes a competency window for stochastic cell fate switching

The paper shows that Nodal signaling creates a temporal window for stochastic cell fate switching in zebrafish embryos, challenging deterministic models of morphogen action.

An improved Erk biosensor reveals oscillatory Erk dynamics driven by mitotic erasure during early development

The paper introduces an improved Erk biosensor to study Erk signaling dynamics in zebrafish and Drosophila embryos, revealing oscillatory dynamics driven by mitotic erasure.