Structural Basis for HIV-1 Maturation Inhibition by PF-46396 Determined by MAS NMR
Roman Zadorozhnyi, Caitlin M. Quinn, Kaneil K. Zadrozny, Sherimay D. Ablan, Brandon J. Kennedy, Glenn P. A. Yap, Daniel Sanner, Christina M. Kraml, Eric O. Freed, Barbie K. Ganser‐Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana E. Polenova
This study determines the atomic structure of HIV-1 CACTD-SP1 assemblies with PF-46396 and IP6 using MAS NMR, revealing binding modes and IP6 dynamics.
Journal of the American Chemical Society · Sep 9, 2025Peer-reviewedBiophysics