Author

Roman Zadorozhnyi

Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA;ORCID 0000-0003-2767-2002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 1

Frequent Co-Authors

Angela M. GronenborniD· 2 shared Barbie K. Ganser-PornillosiD· 2 shared Caitlin M. QuinniD· 2 shared Eric O. FreediD· 2 shared Owen PornillosiD· 2 shared Sherimay D. AblaniD· 2 shared Tatyana E. PolenovaiD· 2 shared Brandon J. KennedyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiophysics

Angela M. GronenbornORCID

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2 papers

Recent·Most cited

Structural Basis of Second-Generation HIV-1 Maturation Inhibitor Activity by Magic Angle Spinning NMR

Kiran Kumar, Roman Zadorozhnyi, Timothy N. Porter, Jayden A. Martinez, Caitlin M. Quinn, Sherimay D. Ablan, Eric O. Freed, Theodore J. Nitz, Carl T. Wild, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

bioRxiv · Nov 6, 2026 · PreprintBiophysics

Structural Basis for HIV-1 Maturation Inhibition by PF-46396 Determined by MAS NMR

Roman Zadorozhnyi, Caitlin M. Quinn, Kaneil K. Zadrozny, Sherimay D. Ablan, Brandon J. Kennedy, Glenn P. A. Yap, Daniel Sanner, Christina M. Kraml, Eric O. Freed, Barbie K. Ganser‐Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana E. Polenova

This study determines the atomic structure of HIV-1 CACTD-SP1 assemblies with PF-46396 and IP6 using MAS NMR, revealing binding modes and IP6 dynamics.

Journal of the American Chemical Society · Sep 9, 2025Peer-reviewedBiophysics