Sherimay D. Ablan

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

This study identifies PLSCR1 as a host restriction factor that inhibits HIV-1 and related viruses by blocking membrane fusion during entry, independent of interferon signaling.

The paper shows HIV-1 NC mutations accelerate viral DNA integration and reduce INSTI sensitivity, acting with IN mutations to confer resistance.

This study determines the atomic structure of HIV-1 CACTD-SP1 assemblies with PF-46396 and IP6 using MAS NMR, revealing binding modes and IP6 dynamics.