CRISPR-Cas13d-mediated targeting of a context-specific essential gene enables selective elimination of uveal melanoma
Daniel Stauber, Lucas Sosnick, Yitong Ma, Sopida Pimcharoen, Atip Lawanprasert, Niren Murthy, David J. Myung, Lei S. Qi
The paper identifies RASGRP3 as a context-specific essential gene in uveal melanoma and develops a CRISPR-Cas13d RNA-targeting therapeutic that selectively eliminates uveal melanoma cells.
Molecular Therapy Oncology · Feb 11, 2026Peer-reviewedSynthetic Biology